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Kanakam Vijayabhaskar ¹, Goli Venkateshwarlu ¹, J. Bhaskar ¹, K. Srisailam ², More Swapna ³

Affiliations
1 Venkateshwara Institute of Pharmaceutical Sciences, Nalgonda. 508002, IN
2 Department of Pharmacy, Satavahana University, Karimnagar. 505001, IN
3 Vaagdevi College of Pharmacy, Warangal. 506001, IN

Abstract

a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the Indian subcontinent. antioxidative potential of the methanol extract of tamarindus indca was evaluated using various antioxidant assays, including DPPH, superoxide, nitric oxide (NO), hydroxyl radical scavenging and ironchelating activity. Total phenolic and flavonoid content of SM was also determined by a colorimetric method. The extract exhibited powerful free radical scavenging, especially against DPPH, hydroxyl radical scavenging and ironchelating activity as well as a moderate effect on NO and superoxide anions. The protective effects of methanol extract of SM were studied in carbon tetrachloride-reduced biochemical markers of hepatic injury such as glutamate pyruvate transaminase (SGPT), serum glutamate oxalaoacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin, cholesterol alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. The increased level of HDL demonstrated dose dependant reduction in the in vivo peroxidation induced by CCl4. Degree of protection was measured by using biochemical parameters such as serum transaminase (GOT and GPT), alkaline phosphatase (ALKP) and bilirubin. Petroleum ether, Ethyl acetate and chloroform extracts did not show any effects. Results obtained in the present study suggest that Tamarindus indica elicits hepatoprotectivity through antioxidant activity on carbon tetrachloride- and paracetamol-induced hepatic damage in rats.

Keywords

Tamarindus indica Hepatoprotective Activity, Antioxidant Effect, Biochemical Parameters.

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S. Sindhuja ¹, J. Bhuvaneswarri ¹, Mohan Valiathan ¹, J. Bhaskar ¹

Affiliations
1 Department of Periodontics, Sree Balaji Dental College and Hospital, BIHER, Chennai, IN

Abstract

Periodontitis is a chronic inflammatory condition, caused by bacteria, that leads to the destruction of supporting tissues around teeth, resulting ultimately in significant morbidity as a result of infection, pain and tooth loss. Curcumin, from the ischolar_main of the turmeric plant Curcuma longa, is an extended pseudo symmetric polyphenol. In recent years, in vitro and in vivo research has suggested that curcumin has anticarcinogenic, antiviral, antioxidant and anti-inflammatory effects. The aim of this review is to systematically evaluate the clinical efficacy and anti inflammatory property of curcumin in periodontal disease. An electronic search was carried out using the keywords ‘curcumin’, ‘periodontal’ and ‘periodontitis’ via the PubMed/Medline, ISI Web of Science and Google Scholar databases for relevant articles published from 2009 to February 2019.

Keywords

Curcumin, Periodontal, Periodontitis, Inflammation.

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Goutham Siriyala ¹, Nithya Anand ², Bagavad Gita ³, J. Bhaskar ², J. Bhuvaneswarri ⁴, S. A. Keerthana ¹

Affiliations
1 Post Graduate Student, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
2 Professor, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
3 Head of the Department, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN
4 Reader, Sree Balaji Dental College and Hospital, BIHER, Department of Periodontics and Implantology, Velachery Main Road, Pallikaranai, Chennai, Tamil Nadu, IN

Abstract

Background: Chronic kidney disease (CKD) is a veryreal and growing problem, as indicated by demographic trends. Presence of undiagnosed periodontitis may have significant effect on the medical management of CKD patient as its been found to contribute to systemic inflammatory burden.This study evaluate and compare the periodontal status and IL-6 levels among CKD, periodontitis and Healthy patients.

Materials and Method: Whole serum samples werecollected from 80 patients who were further divided into four groups; healthy (n=20), periodontitis (n=20), HD (n=20), PD (n=20). Serum IL-6 concentrations were determined by Standard enzyme -linked immunosorbent assay.

Results: Indicates the IL-6 levels in the studypopulation. The mean IL-6 value being highest in pre-dialysis (92.695) compared to dialysis (53.112), periodontitis (9.22) and healthy individuals (9.6). ANOVA results show a significant increase of IL-6 levels in the pre-dialysis group compared to alter groups. No significant change on PPD was appreciated.

Conclusion: Treatment of moderate to severeperiodontitis in ESRD populations will result in decreased IL-6 levels and, more importantly, decreased incidence of atherosclerotic complications awaits the result of interceptive clinical trials in this population

Keywords

Chronic Renal Disease, Periodontitis, Interleukin 6, End Stage Renal Disease, Dialysis, Periodontal Status.

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